Zancong Shen, Colin Rowlings, Brad Kerr, Vijay Hingorani, Kimberly Manhard, Barry Quart, Li-Tain Yeh, Chris Storgard Ardea Biosciences, Inc.(a member of the AstraZeneca group), San Diego, CA, USA Abstract: Lesinurad is a selective uric acid reabsorption inhibitor under investigation for the treatment of gout.Single and multiple ascending dose studi
Aim: The aim of this study was to assess the utility of weighted amide proton transfer (APTw) MRI in three different rodent models of hepatocellular carcinoma (HCC).Methods: APTw MRI was evaluated in models of diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft and human HepG2 ectopic xenograft.Results: All models of aireloom
In this work, we designed a tetranuclear self-assembled dye 4 (2Z907-Ag+-(Ru(TMAM))) exploiting a combination of the antenna effect and positively-charged groups designed to repel the oxidized form of cationic cobalt redox mediators, in order to reduce recombination and increase the efficiency of dye sensitized solar cells (DSSCs).Charge transfer a
Hypertensive urgency is a major risk factor for cardiovascular events and premature deaths.Lack of medication adherence is associated with poor health outcomes among patients with hypertensive urgency in resource-limited settings.To inform the development of tailored interventions to improve health outcomes in this population, this study aimed at u